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[Ala16,17,20]-β-Amyloid (1-28)

Name
[Ala16,17,20]-β-Amyloid (1-28)
Molecular structural formula
Purity
95%
Formula
C133H192N40O46
MW
3087.19
Sequence
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Ala-Ala-Val-Phe-Ala-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys
Sequence Shortening
DAEFRHDSGYEVHHQAAVFAAEDVGSNK
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Product details
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This is a mutated β-Amyloid 1 to 28 amino acids sequence in which the KLVFF sequence (Ab16-20) is substituted with AAVFA. The KLVFF is the shortest peptide displaying consistent high binding capacity to full-length Aβ. The first, second, and fifth residues (i.e. KLXXF) are critical for binding. The substitutions in this Aβ (1-28) amino acids sequence in the 16 to 20 region profoundly impair the ability of the peptide to aggregate and form amyloid-like fibrils.